Frequently Asked Questions

What is a purification?

A purification is an individual experiment consisting of a protein, which is modified (tagged) and subsequently purified to retrieve additional members of protein complexes.

How do you map purifications to inferred complexes?

The computation of the complexes relies on pairwise interactions between proteins. Please referr to the supplementary material of our publication for details. Proteins from one purification do not necessary appear in the same complex as some proteins are regardes as part of another complex or as a contaminant. Consequently, it is not possible to map complexes to purifications. We assign a purification to a complex if one of the members is a core module and at least one additional protein is part of the purification. Please check the isoform link, which will give you a view different view of the complex under inspection.